Quantitative Characterization of Shear-Induced Platelet Receptor Shedding: Glycoprotein Ibα, Glycoprotein VI, and Glycoprotein IIb/IIIa
نویسندگان
چکیده
منابع مشابه
Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα.
Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic drag. The increased interaction requires shear-dependent exposure of the von Willebrand factor A1 domain, but the contribution of glycoprotein Ibα...
متن کاملCritical role of platelet glycoprotein ibα in arterial remodeling.
OBJECTIVE Arteriogenesis is strongly dependent on the recruitment of leukocytes, especially monocytes, into the perivascular space of growing collateral vessels. On the basis of previous findings that platelets are central players in inflammatory processes and mediate the recruitment of leukocytes, the aim of this study was to assess the role of platelets in a model of arterial remodeling. AP...
متن کاملTHROMBOSIS AND HEMOSTASIS Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa
1Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; 2Department of Haematology, The Alfred Hospital, Melbourne, Australia; 3Diagnostic Haematology, Melbourne Health, Royal Melbourne Hospital, Melbourne, Australia; 4Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; and 5Biomedi...
متن کاملA critical role of platelet glycoprotein Ibα in arterial remodeling.
T he canonical role of platelets is hemostasis in which they function as highly specialized cells designed to plug holes in the blood vascular system. To accomplish this task, platelets have evolved unique molecular tools that enable them to function in the vascular environment, such as the GPIbα receptor complex that mediates platelet adhesion to the vessel wall in the face of high shear force...
متن کاملAdhesion Maturation of Neutrophils on Nanoscopically Presented Platelet Glycoprotein Ibα
Neutrophilic granulocytes play a fundamental role in cardiovascular disease. They interact with platelet aggregates via the integrin Mac-1 and the platelet receptor glycoprotein Ibα (GPIbα). In vivo, GPIbα presentation is highly variable under different physiological and pathophysiological conditions. Here, we quantitatively determined the conditions for neutrophil adhesion in a biomimetic in v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ASAIO Journal
سال: 2018
ISSN: 1058-2916
DOI: 10.1097/mat.0000000000000722